IGF-1 LR3 1mg - DRIADA MEDICAL


1 vial x 1 mg + bac.water




Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).

WHAT IS IGF-1?
Insulin-like Growth Factor 1 (IGF-1) is a vital protein that plays an integral role in human growth and development. This recombinant human protein, which belongs to the insulin-like growth factor family, consists of 70 amino acids and functions similarly to insulin. It is involved in the regulation of various bodily processes, including cell growth, development, and differentiation, through endocrine, autocrine, and paracrine pathways.

One of the intriguing aspects of IGF-1 is its connection to aging. Research suggests that mutations in the IGF-1 gene can increase lifespan in laboratory animals, highlighting its potential impact on longevity. In children, IGF-1 is essential for stimulating cell growth and differentiation, while in adults, it continues to exert anabolic effects, promoting tissue growth and maintenance.

IGF-1 operates within a complex network of growth factors, receptors, and binding proteins that mediate cell proliferation, differentiation, and apoptosis. These growth factors are low-molecular-weight proteins present in nearly all tissues, where they regulate cell division, growth, and migration. In the skin, for instance, they are crucial for the migration and development of epithelial cells and stimulate cell division.

Often referred to as somatomedin C, IGF-1 serves as a key mediator of the growth hormone (HGH) effects. It is primarily produced by liver hepatocytes in response to growth hormone stimulation. The liver’s production of IGF-1 is influenced by various hormones, including sex steroids, thyroid hormones, glucocorticoids, and insulin. Insulin, androgens, and estrogens tend to enhance IGF-1 secretion, whereas glucocorticoids inhibit it. This interplay explains the synergy between these hormones in growth and development processes and the inhibitory impact of glucocorticoids on growth and puberty.

Throughout life, IGF-1 levels fluctuate, peaking during adolescence and dipping during childhood and old age. Despite these variations, IGF-1 remains a crucial anabolic hormone. It is secreted by various tissues, with the liver being the primary source, releasing IGF-1 into the bloodstream to act as an endocrine hormone. Other tissues, including cartilage cells, also secrete IGF-1, where it functions locally as a paracrine hormone.

In recent years, IGF-1 has garnered attention in the sports world as a doping agent, featuring in numerous high-profile doping cases. Its ability to enhance growth and performance makes it a substance of interest and concern in athletic communities.

. MAIN EFFECTS
IGF-1 is an extremely powerful anabolic, which in combination with anabolic steroids gives a very large increase in lean muscle mass. At the same time, IGF-1 has a lot of other useful properties that together create the maximum boost for growth. IGF-1 is a product that can increase your result when other methods no longer give a significant effect.

Anabolic effects
Increase in muscle mass (various ways of exposure)
Muscle hyperplasia (unique property of increasing the number of muscle cells)
Accelerated protein synthesis
Regeneration of tendon tissue (increases collagen synthesis)
Has a restorative effect on cartilage tissue
Increases the effectiveness of anabolic steroids (increases the number of androgen receptors)
Restores and strengthens bone and cartilage tissue
Support of the cardiovascular system
Improves cardiac output, stroke volume, contractility and ejection fraction.
Stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction.
Improves lipid profile
Reduces insulin levels, increases insulin sensitivity and promotes glucose metabolism
Reducing the overall risk of cardiovascular complications
Helps fight inflammatory processes
Nerve tissue
Increases glucose transport in nervous tissue
Protects neurons at low glucose levels, preventing cell destruction.
Play an important role in the restoration of neurons and nervous tissue in general
Other effects
Regulate the expression of genes that increase life expectancy.
Accelerates the restoration of the skin, prevents skin aging
Improved immunity

Storage
Proper storage of peptide drugs is crucial to maintaining their effectiveness. Below are the guidelines for storing peptides in various forms.

Storage of the Powder Form
The powder form (unmixed) can be stored at room temperature or in the refrigerator. Lyophilized powder should be kept away from direct sunlight and excessive heat. Under appropriate storage conditions, peptides in dry form can be stored for up to 3 years at 2-8°C and up to 2 years at 15-30°C. If the vial is damaged and air gets inside, the active substance will decompose quickly outside the refrigerator, retaining only about half of its concentration within two weeks. Therefore, if the packaging's integrity is uncertain, it is best to store the peptide in the refrigerator.

Storage of Bacteriostatic Water
Bacteriostatic water should always be stored in the refrigerator at 2-8°C to maintain its properties. If the peptide and bacteriostatic water are stored together, keep the entire set in the refrigerator.

Storage of the Solution
After mixing the powder with water from the ampoule, the peptide solution must be stored in the refrigerator. Without refrigeration, the peptide begins to degrade, and within a few days, the molecules will break down completely. The storage duration for each peptide varies. For instance, growth hormone can be stored in the refrigerator for only 2-3 days, while HCG can last about 5 weeks. On average, other peptides can be stored for at least 30 days, though some may last even longer. The degradation rate also depends on the number of bacteria introduced when piercing the vial, which is unavoidable to some extent.

!!! NEVER STORE PEPTIDES IN THE FREEZER !!!

USE WITH ANABOLIC STEROIDS
It is also perfectly appropriate to use IGF-1 with anabolic steroids and other drugs with similar effects. IGF-1-1 enhances the effects of anabolic steroids by increasing the number of androgen receptors. The drug IGF-1 is an extremely powerful anabolic that, in combination with AS, gives a very large increase in lean muscle mass. At the same time, IGF-1 has a lot of other useful properties that together create the maximum background for growth.

All anabolic steroids act on muscles through special structures – receptors. There is an opinion that if you use steroids for a long time, the number of these receptors decreases. The number of these receptors also decreases with age. In this case, it becomes necessary to use large doses of steroids. In 20 years, 300 mg of testosterone Propionate acts more powerfully than in 30 years. At 30 years of age, 600 mg is needed for the same effect. IGF-1 activates cells and increases the number of androgen receptors, and at 30 years of age, then 300 mg of testosterone propionate will act the same as at 20 years of age.

Effects
USE WITH GROWTH HORMONE (SOMATROPIN)
The use of somatotropin at the same time may be advisable, although it may not seem logical at first glance, nevertheless, many professional bodybuilders do just that. When used together, their effects add up – as an anabolic effect for muscle growth, and for the restoration and regeneration of cartilage and other collagen structures. Also, growth hormone and IGF-1 together will increase fat burning.

It should be borne in mind that in addition to beneficial effects, the presence of side effects may also occur. It should be understood that the level of IGF when using both drugs will increase significantly, so such use should not be prolonged.

Effects
USE WITH INSULIN
As the name IGF-1 implies, it has a structure similar to insulin, and binds not only to its own IGF1R receptor, but also to the insulin receptor — and vice versa. However, the binding affinity for IGF1R and the insulin receptor, respectively, is different, with a high affinity of IGF-1 for IGF1R and about 10 times lower affinity for the insulin receptor.

On the other hand, the affinity of insulin to its own receptor is about 100 times higher compared to IGF1R. Moreover, despite the similarity in structure, IGF-1 and insulin show different distribution in tissues, different internalization kinetics and different subcellular distribution of hormonal receptors. Consequently, both hormones can affect similar pathways, but to different degrees, and, in addition, differentially activate other pathways located downstream.

These hormones can be compared in the plane of the effect on glucose metabolism in the body. When they are used together, such a side effect as hypoglycemia (a drop in sugar levels) will be so pronounced that it will create risks to life.

Effects
Synergistic increase in muscle mass
Synergistic effect of fat burning
Strengthening the action of anabolic steroids
Synergistic effect on strengthening bone tissue
Synergistic increase in muscle mass
Synergistic effect of fat burning
Synergistic effect on tendon repair
Synergistic effect on strengthening bone tissue
Increased risk of side effects from excessive IGF-1 levels
Synergistic increase in muscle mass
Increased risk of hypoglycemia