PROPIOS (ampoules) - DRIADA MEDICAL

10 amps x 1 ml x 100 mg/ml

Carrier: Sesame Oil




DESCRIPTION
Testosterone is the primary sex hormone in humans, playing a crucial role in the development of male and female reproductive tissues, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, body hair growth, and overall well-being. Testosterone is essential for maintaining health and preventing conditions like osteoporosis. In men, insufficient levels of testosterone can lead to frailty and bone loss. Testosterone is not only used by athletes for muscle building but also has medical applications for conditions such as gender dysphoria, male hypogonadism, and certain types of breast cancer.

MECHANISM OF ACTION
Testosterone binds to androgen receptors and serves as a precursor to another biologically active androgen called dihydrotestosterone (DHT), which is formed through the action of the enzyme 5α-reductase on testosterone. DHT has a higher affinity for androgen receptors compared to testosterone. These hormones bind to androgen receptors, triggering changes in gene activity and mediating androgenic effects. Testosterone can also be converted to estrogen through the process of aromatization. Estrogens, rather than testosterone, predominantly activate feedback mechanisms and suppress the secretion of endogenous testosterone when exogenous testosterone is administered.

MEDICAL USE
Testosterone is included in the World Health Organization's list of essential medicines, highlighting its importance in basic healthcare. It is used as a medication for the treatment of gender dysphoria, male hypogonadism, and certain types of breast cancer. Hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) may be necessary to maintain testosterone levels within the normal range, especially as men age and experience declining testosterone production. Testosterone replacement therapy can improve well-being, sexual function, and overall body composition.

Testosterone for Seniors
Men over the age of 35 who experience a decline in well-being are often recommended to have their testosterone levels tested. If levels are below 12 nmol/l, hormone replacement therapy may be offered. This approach has several positive effects, including improvements in body composition (reduced fat, increased muscle mass), rejuvenated sexual function, and an overall reversal of the negative effects associated with androgen deficiency. Regular monitoring of lipid profiles, blood parameters, estradiol, and prolactin levels is essential. Additionally, for individuals desiring to have offspring, specific therapy with gonadotropins may be required.

Testosterone in Sports
The main advantage of testosterone in sports is its ability to increase muscle mass and strength. It has both anabolic and androgenic effects. Androgens interact with androgen receptors, leading to changes in gene expression and protein synthesis. Testosterone can also promote water retention, joint health, regeneration processes, and enhanced oxygen-carrying capacity in the blood. Typical dosages in sports range from 250 to 500 mg per week, with adjustments based on an athlete's body weight. Testosterone cycles usually last 8 to 10 weeks, followed by post-cycle therapy. Regular monitoring of estradiol levels and the use of aromatase inhibitors are important to manage potential estrogenic side effects.

Dosages
Beginner: 50 mg every other day (E OD)
Average Dosage: 100-150 mg EOD
High Dosage: 100 mg or more per day (ED)
Effects
Increased muscle mass
Development of male genital organs and secondary sexual characteristics
Spermatogenesis and male sexual behavior
Enhanced muscle strength
Reduction in blood cholesterol levels
Lower risk of heart ischemia and coronary heart disease
Stimulation of erythropoiesis
Influences nitrogen and phosphorus metabolism
Side Effects
Increased blood pressure
Heightened sexual behavior
Increased blood clotting tendency
Possible formation of blood clots in arteries and veins
Water retention (edema)
Masculinization effects
Aggression, agitation, irritability
Alopecia (baldness)
Acne
Insomnia (rare)
Profile
Half-life: 20 hours
Frequency of Injections: 1-2 days
Pharmaceutical Form
Oily solution for intramuscular injection
Contraindications
Pregnancy
Known or suspected carcinoma of the prostate or breast
Breastfeeding
Hypersensitivity to the active substance or any excipients
HOW TO STORE
Do not use after the expiry date
Store between 8º to 30ºC
Avoid freezing
Protect from light