Tesofensine is an innovative Triple Serotonin Norepinephrine Dopamine Reuptake Inhibitor (SNDRI), representing a new generation of psychoactive antidepressants. This compound acts on vital neurotransmitters in the brain, including serotonin, norepinephrine, and dopamine. Initially developed by NeuroSearch A/S in Denmark, Tesofensine was originally designed to address the challenges posed by Parkinson's and Alzheimer's diseases.



Effects:

Appetite Suppression: Tesofensine acts centrally to curb appetite, leading to a significant decrease in food cravings. Users typically experience a higher level of satiety and reduced desire to eat, often within a span of 14 days.

Fat Oxidation and Adipose Tissue Reduction: Tesofensine substantially boosts fat oxidation and contributes to the reduction of adipose tissue, aiding in weight management.

Insulin Sensitivity: This compound improves insulin sensitivity, which, in turn, enhances glucose metabolism, making it beneficial for individuals with metabolic concerns.

Dopaminergic Receptor Alteration: Tesofensine has the capacity to modify the expression of dopaminergic receptors in the brain's striatum and influence their binding.

Enhanced Energy Consumption: Users often report a significant increase in energy expenditure over a 14-day period.

Extended Half-Life: Tesofensine boasts a prolonged half-life of 8-9 days, with primary metabolism occurring in the liver, where it forms the disalkyl metabolite M1 (NS-2360), the exclusive metabolite detected in human blood plasma.



Potential Side Effects:

Gastrointestinal Distress: Some users may experience gastrointestinal issues, such as nausea, diarrhea, or constipation.

Cardiovascular Effects: Tesofensine might have an impact on heart rate and blood pressure, potentially leading to adverse cardiovascular effects. Regular monitoring of these parameters is advisable.

Psychological Effects: There is a possibility of psychological side effects, including mood changes, anxiety, or insomnia.

Interactions: Tesofensine may interact with other medications or pre-existing medical conditions, necessitating careful consideration and medical guidance.



Dosage Instructions:

A typical dosing regimen for Tesofensine may involve a daily intake, starting at lower doses, such as 0.5 mg or 1 mg, and gradually increasing as tolerated.
Dosing may be adjusted based on individual response, but it is essential to adhere to recommended guidelines.
Due to its long half-life, it is critical to maintain a consistent dosing schedule and avoid abrupt discontinuation.